Bioactive Small Molecules
Selleck Chemical LLC 3 3-Dimethyl-1-butanol E4432-100MG
3 3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) 3 3-dimethyl-1-butanol negatively inhibits the signalling pathways of p65 NF- B and TGF- 1/Smad3 3 3-dimethyl-1-butanol has potential applications in cardiovascular disease (CVD)
Selleck Chemical LLC Olprinone Hydrochloride E4979-100MG
Olprinone hydrochloride(Loprinone Hydrochloride E-1020) is a potent inhibitor of phosphodiesterase (PDE) 3 with an IC50 value of 0 35 M for PDE3 respectively Olprinone Hydrochloride is used in the research of heart failure treatment due to its positive inotropic and vasodilatory effects It also exhibits anti-inflammatory properties
Selleck Chemical LLC Lumateperone Tosylate E4874-100MG
Lumateperone tosylate(ITI-007) is an antagonist of 5-HT2A receptor It also acts as a partial agonist of presynaptic D2 receptors as an antagonist of postsynaptic D2 receptors and as a modulator of dopamine D1 receptor Lumateperone tosylate demonstrates anticancer activity
![Medchemexpress LLC 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one | 510-74-7 | 99.2% | 383.46 | C22H26FN3O2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211675.png-250.jpg)
Medchemexpress LLC 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one | 510-74-7 | 99.2% | 383.46 | C22H26FN3O2 | 25 MG
Spiramide (AMI-193) is a research-grade small molecule antagonist of serotonin 5-HT2 and dopamine D2 receptors. It is supplied as a solid or as a DMSO solution for in vitro pharmacology, receptor binding, and functional assays. The compound demonstrates high potency and selectivity and is intended for laboratory research use only.
- Potent antagonist of 5-HT2 and dopamine D2 receptors (Ki = 2 nM and 3 nM).
- High selectivity versus 5-HT1C receptors (Ki = 4,300 nM).
- Available as solid and as 10 mM solution in DMSO in multiple small pack sizes.
- Purity typically greater than 99% by supplier analysis.
- Molecular weight 383.46; CAS 510-74-7.
- For research use only; not for human or veterinary use.
![Medchemexpress LLC 1-[(2R)-1-methylsulfonylpropan-2-yl]-4-(trifluoromethyl)indole-5-carbonitrile | 1539314-06-1 | MFCD30343844 | 99.4% | 330.33 g/mol | C14H13F3N2O2S | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215869.png-250.jpg)
Medchemexpress LLC 1-[(2R)-1-methylsulfonylpropan-2-yl]-4-(trifluoromethyl)indole-5-carbonitrile | 1539314-06-1 | MFCD30343844 | 99.4% | 330.33 g/mol | C14H13F3N2O2S | 25 MG
GSK-2881078 is an orally active, nonsteroidal selective androgen receptor modulator used in preclinical research on muscle weakness and cachexia. It functions as a partial AR agonist and produces AR-mediated transcriptional activation in cellular assays. The compound is supplied as a characterized powder with established purity and storage recommendations for laboratory use.
- Orally active nonsteroidal selective androgen receptor modulator.
- Demonstrated AR-mediated transcriptional activation in cell assays.
- High purity (99.42%) suitable for research applications.
- Solid white to off-white powder form for easy handling.
- Defined storage conditions to preserve stability.
- Available in multiple package sizes for experimental flexibility.
Medchemexpress LLC Ursodeoxycholic acid-d4 | 347841-46-7 | 99.5% | 396.60 | 1 MG
Ursodeoxycholic acid-2,2,4,4-d4 is a deuterium-labeled form of Ursodeoxycholic acid (UDCA), a secondary bile acid. It plays a role in regulating intestinal barrier integrity and is crucial for lipid metabolism. It functions as a signaling molecule by interacting with bile acid-activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR).
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Beneficial for reducing SARS-CoV-2 infection by reducing ACE2 expression
- Research on various hepatic and gastrointestinal diseases
- Stable heavy isotopes for quantitation during drug development
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs
- Appearance: Solid, white to off-white
Medchemexpress LLC Monocarboxylic Acid Transporter 1 Antibody (YA3244) | 10 UL
Monocarboxylic Acid Transporter 1 Antibody (YA3244) is a rabbit-derived, non-conjugated IgG monoclonal antibody, specifically targeting Monocarboxylic Acid Transporter 1. This protein acts as a proton-linked monocarboxylate transporter, crucial for moving substances such as lactate and pyruvate across cell membranes. Mutations in the gene associated with this transporter can lead to erythrocyte lactate transporter defects.
- Rabbit-derived, non-conjugated IgG monoclonal antibody
- Targets monocarboxylic acid transporter 1
- Reactivity: Human
- Molecular weight: 54 kDa
- Purity: Affinity purified
- Application: WB, with a dilution ratio of 1:500-1:1000
- Formulation includes 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Storage at -20°C for 1 year, avoiding repeated freeze/thaw cycles
- Appearance: Liquid
Medchemexpress LLC Ncgc00244536 | 2003260-55-5 | MFCD31382180 | 99.7% | 382.45 g/mol | C25H22N2O2 | 1 MG
NCGC00244536 is a small-molecule inhibitor of the histone demethylase KDM4B with a reported IC50 of 10 nM. Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies investigating KDM4B-dependent processes.
- Potent KDM4B inhibition (IC50 10 nM).
- High purity: 99.7%.
- Solid, light yellow to green yellow appearance.
- Molecular formula C25H22N2O2; molecular weight 382.45 g/mol.
- Available in milligram pack sizes suitable for research use.
- Suitable for biochemical and cellular research applications.
Cayman Chemical ANTIBODY ERD-308 500ug
A PROTAC that drives ER degradation; induces degradation of ERα in MCF-7 and T47D cancer cells (DC50s = 0.17 and 0.43 nM, respectively); inhibits the growth of MCF-7 cells (GI50 = 0.77 nM); reduces the levels of mRNA encoding progesterone receptor and GREB1 in MCF-7 cells at 1 to 300 nM
Cayman Chemical DMU2105, Purity: ≥98%, CAS: 1031063-36-1, 50 mg
A CYP1B1 inhibitor (IC50 = 0.01 µM); selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.742, 1.2, 18, and 10 µM, respectively); enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1
Apexbio Technology LLC Monobenzone 103-16-2 10mM (in 1mL DMSO)
Monobenzone is a small-molecule inhibitor targeting tyrosinase It is designed to inhibit the enzyme tyrosinase thereby disrupting the melanin biosynthesis pathway and reducing melanin production Monobenzone exerts its biological activity primarily through inhibition of tyrosinase activity Based on these pharmacological properties Monobenzone holds research potential in studies on melanoma vitiligo mechanisms melanin regulation and in generating depigmented animal models and cellular assays for investigating pigment synthesis melanocyte biology and related autoimmune responses
Cayman Chemical Baccatin III, Purity: ≥98%, CAS: 27548-93-2, 5 mg
A precursor of paclitaxel and an apoptotic agent; induces apoptosis in JR4-Jurkat leukemia, HepG2 liver hepatocellular carcinoma, HeLa cervical, OVCAR-3 ovarian carcinoma, and T47D breast cancer cell lines (IC50s = 3.5, 3, 4, 5, and 2 μM, respectively); increases APC capacity of BM-DCs; decreases tumor growth of 4T1 mammary carcinoma and CT26 colon carcinoma flank implants as well as inhibits the accumulation and activity of MDSCs in spleen in immunocompetent mice
Cayman Chemical Nefiracetam, Purity: ≥98%, CAS: 77191-36-7, 5 mg
An analytical reference standard categorized as a nootropic; intended for research and forensic applications
Medchemexpress LLC HY-B1986 100mg Medchemexpress, p,p'-DDE CAS:72-55-9 Purity:>98%
Medchemexpress, HY-B1986 100mg p,p'-DDE CAS:72-55-9 p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Ubpbio Doxorubicin HCL, 5MG
Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.